Our Research
Cognitive Neuroscience, Biological and Artificial Intelligence
Understanding the link between human cognition and brain structural and functional architecture is a key building block of the program. We are looking at the neural correlates of global phenomenon like general and fluid intelligence in humans, as well as at the interplay between different brain networks necessary to generate fine cognitive skills such as memory, attention, mental flexibility. In particular, we focus on dynamic brain states analysis, looking at how brain activity evolves over time by extracting spatio-temporal patterns able to inform closed-loop feedback applications. The study of intelligence, creativity and memory is also revealing essential in informing models of artificial intelligence (A.I.) aimed at mimicking human cognition and decision making, including learning models and theories of consciousness.
Brain Health, Longevity and Pathological Aging
Brain health is becoming a key aspect of modern-day life, and a successful predictor of healthy aging. We are interested in both cognitive and neural aspect of brain health, spanning from the idea of brain resilience to external perturbation to the role of brain efficiency and brain plasticity, also looking at how these factors interact in the context of cognitive reserve. We are particularly interested on how changes in connectomics and brain oscillatory activity (e.g., gamma and theta activity) might lead to cognitive decline and impairment of quality of life. We are currently running clinical trials investigating experimental therapeutic opportunities for the treatment of conditions such as Alzheimer’s disease and Frontotemporal dementia, including studies involving the application of noninvasive brain stimulation techniques.
Noninvasive Brain Stimulation and Connectome Rewiring
The program addressed the need for personalized, image-guided solutions to modulate brain “activity” and manipulate the human brain connectome, for both cognitive enhancement and clinical applications. Brain imaging and electrophysiology techniques such as fMRI, EEG, MEG, are combined with noninvasive brain stimulation methods such as Transcranial Magnetic Stimulation (TMS) and transcranial electrical stimulation (tES) to create a “Perturbation-based” causal connectome, as well as to identify optimal targets to induce brain state-to-state and trait-to-trait change. Approaches including network control theory and evolutionary game theory models of brain functioning are used to identify personalized stimulation targets and maximize brain control, while techniques like cortico-cortical paired associative stimulation (ccPAS) TMS and transcranial alternating current stimulation (tACS) are leveraged to induce synchronization of brain networks. Recent efforts have been pointed in the direction of modulation of the brain cancer connectome (Sprugnoli et al.).
Brain Plasticity, Learning and Cognitive Enhancement
The impact of external perturbation on brain and cognitive dynamics is evaluated via various approaches, with the goal of understanding how the brain adapt to novel stimuli in the context of brain plasticityprocesses, including the role of sleep and memory consolidation. Given the unique insight offered by the response to different interventions, our studies focus on a variety of interventions, ranging from psychotherapy to meditation, motor learning, dietary supplements, cognitive training and videogames. Given its impact on performance, our work is expanding on clinical and non-clinical areas, including research on Space physiology and the development of potential countermeasures to maintain optimal brain performance in extreme environments such as during space flight.
Clinical Biomarkers Discovery and Therapeutic Applications
We use multimodal neuroimaging and electrophysiology to identify novel biomarkers of neurological and psychiatric conditions, using techniques such as combined TMS-EEG, tACS-EEG, fMRI, DTI and PET. When potential biomarkers have been identified, we promote experimental therapeutic solutions including those based on noninvasive brain stimulation. Recent work by our group has focused on neurodegenerative disorders such as Alzheimer’s disease and related dementias, brain tumors, depression and disorders of consciousness.